OUL 35

Names

[ CAS No. ]:
6336-34-1

[ Name ]:
OUL 35

[Synonym ]:
4.4'-Oxy-bis-benzamid
4,4'-oxy-di-benzoic acid diamide
4,4'-oxydibenzamide
4,4'-Oxy-di-benzoesaeure-diamid

Biological Activity

[Description]:

OUL35 (NSC39047) is a potent and selective inhibitor of ARTD10 (PARP-10), with an IC50 of 329 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

ARTD10/PARP10:329 nM (IC50)

[In Vitro]

OUL35 rescues HeLa cells from ARTD10-induced cell death and sensitizes cells to DNA damage. OUL35 (3 μM) binds to endogenous ARTD10 in U2OS cells[1]. OUL35 also inhibits ARTD8 (23.4 μM), ARTD4 (22.6 μM), and ARTD15 (4.17 μM) but with modest potency[1]. OUL35 makes hydrogen bonds to the amide and carbonyl of Gly888 and to the side-chain hydroxyl of Ser927. OUL35 stacks between Tyr919 and Tyr932, like 3AB in the crystal structure[1].

[References]

[1]. Harikanth Venkannagari, et al. Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage. Cell Chem Biol. 2016 Oct 20;23(10):1251-1260.

Chemical & Physical Properties

[ Density]:
1.298g/cm3

[ Boiling Point ]:
488.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₂N₂O₃

[ Molecular Weight ]:
256.25700

[ Flash Point ]:
257.9ºC

[ Exact Mass ]:
256.08500

[ PSA ]:
95.41000

[ LogP ]:
3.07730

[ Index of Refraction ]:
1.633

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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