2',3'-Didehydro-2',3'-dideoxyuridine

Names

[ Name ]:
2',3'-Didehydro-2',3'-dideoxyuridine

[Synonym ]:
ddeUrd
D4U
2',3'-Dideoxyuridinene
2',3'-Didehydro-2',3'-dideoxyuridine

Biological Activity

[Description]:

2',3'-Didehydro-2',3'-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.448g/cm3

[ Boiling Point ]:
443.4ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₁₀N₂O₄

[ Molecular Weight ]:
210.19

[ Flash Point ]:
221.9ºC

[ Exact Mass ]:
210.06400

[ PSA ]:
84.32000

[ Index of Refraction ]:
1.592

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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