2',3'-Dideoxy-5-iodouridine

Names

[ CAS No. ]:
105784-83-6

[ Name ]:
2',3'-Dideoxy-5-iodouridine

[Synonym ]:
2',3'-Dideoxy-5-iodouridine
5-Iodo-2',3'-dideoxyuridine
Uridine,2',3'-dideoxy-5-iodo
5-I-ddU
MFCD00074877

Biological Activity

[Description]:

2',3'-Dideoxy-5-iodouridine is used for gene sequencing and as a research tool for antiviral and anticancer studies[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Dinesh Rai, et al. Inhibition of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium avium by novel dideoxy nucleosides. J Med Chem. 2007 Sep 20;50(19):4766-74.

Chemical & Physical Properties

[ Density]:
2.02g/cm3

[ Melting Point ]:
176ºC (dec.)(lit.)

[ Molecular Formula ]:
C₉H₁₁IN₂O₄

[ Molecular Weight ]:
338.09900

[ Exact Mass ]:
337.97600

[ PSA ]:
84.32000

[ Index of Refraction ]:
1.682

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A system for rapid DNA sequencing with fluorescent chain-terminating dideoxynucleotides.

Science 238(4825) , 336-41, (1987)

A DNA sequencing system based on the use of a novel set of four chain-terminating dideoxynucleotides, each carrying a different chemically tuned succinylfluorescein dye distinguished by its fluorescen...

Aldrichimica Acta 20 , 52, (1987)