5’-O-Acetyl-2’,3’-dideoxy-2’,3’-didehydro-uridine

Names

[ CAS No. ]:
42867-74-3

[ Name ]:
5’-O-Acetyl-2’,3’-dideoxy-2’,3’-didehydro-uridine

[Synonym ]:
Uridine,2',3'-didehydro-2',3'-dideoxy-,5'-acetate

Biological Activity

[Description]:

5’-O-Acetyl-2’,3’-dideoxy-2’,3’-didehydro-uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H12N2O5

[ Molecular Weight ]:
252.22

[ Exact Mass ]:
252.07500

[ PSA ]:
90.65000

Precursor & DownStream

Precursor

DownStream