Uridine, 2',3'-didehydro-2',3'-dideoxy-5-fluoro- (9CI)

Names

[ Name ]:
Uridine, 2',3'-didehydro-2',3'-dideoxy-5-fluoro- (9CI)

[Synonym ]:
2',3'-Didehydro-2',3'-dideoxy-hexopyranosyl cytidine

Biological Activity

[Description]:

2′,3′-Didehydro-2′,3′-dideoxy-5-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.57g/cm3

[ Molecular Formula ]:
C₉H₉FN₂O₄

[ Molecular Weight ]:
228.18

[ Exact Mass ]:
228.05500

[ PSA ]:
84.32000

[ Index of Refraction ]:
1.609

Uridine, 2',3'-didehydro-2',3'-dideoxy-5-fluoro- (9CI)

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds