Carnosol

Names

[ Name ]:
Carnosol

[Synonym ]:
(7β)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one
(7β)-11,12-Dihydroxy-7,20-epoxyabieta-8(14),9(11),12-trien-20-one
2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10aS)-
Carnosol

Biological Activity

[Description]:

Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM.

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)

Natural Products >> Phenols

Research Areas >> Cancer

[Target]

IC50: 5.5 μM (RSK2)[1].

[In Vitro]

It is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1[1].

[In Vivo]

Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged[1].

[Animal admin]

Mice[1] Mice are orally administrated Carnosol at 100 mg/kg or vehicle 5 times a week over a period of 31 days[1].

[References]

[1]. Wang L, et al. Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2. Oncotarget. 2018 Feb 6;9(76):34200-34212.

[Related Small Molecules]

BI-D1870 | CMK | PF-4708671 | LY-2584702 tosylate salt | BIX 02565 | AT7867 | Pluripotin | Quercitrin | A-196 | LJI308 | LJH-685 | AT13148

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
524.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₆O₄

[ Molecular Weight ]:
330.418

[ Flash Point ]:
187.0±23.6 °C

[ Exact Mass ]:
330.183105

[ PSA ]:
66.76000

[ LogP ]:
3.71

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.607

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
F+

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Articles

Calcium and α-tocopherol suppress cured-meat promotion of chemically induced colon carcinogenesis in rats and reduce associated biomarkers in human volunteers.

Am. J. Clin. Nutr. 98(5) , 1255-62, (2013)

Processed meat intake has been associated with increased colorectal cancer risk. We have shown that cured meat promotes carcinogen-induced preneoplastic lesions and increases specific biomarkers in th...

Degradation study of carnosic acid, carnosol, rosmarinic acid, and rosemary extract (Rosmarinus officinalis L.) assessed using HPLC.

J. Agric. Food Chem. 60(36) , 9305-14, (2012)

Rosemary, whose major caffeoyl-derived and diterpenoid ingredients are rosmarinic acid, carnosol, and carnosic acid, is an important source of natural antioxidants and is being recognized increasingly...

Relevance of carnosic acid, carnosol, and rosmarinic acid concentrations in the in vitro antioxidant and antimicrobial activities of Rosmarinus officinalis (L.) methanolic extracts.

J. Agric. Food Chem. 60(38) , 9603-8, (2012)

The importance of the diterpenic and rosmarinic acid content in the biological activities of rosemary extracts has been studied previously, but how the relationship between the concentration of these ...