D-Glucose 6-Phosphate

Names

[ CAS No. ]:
56-73-5

[ Name ]:
D-Glucose 6-Phosphate

[Synonym ]:
EINECS 200-286-9
MFCD00136040
d(+)-glucopyranose 6-phosphate

Biological Activity

[Description]:

D-Glucose 6-Phosphate is a glucose sugar phosphorylated at the hydroxy group on carbon 6.

[Related Catalog]:

Research Areas >> Metabolic Disease

Natural Products >> Saccharides and Glycosides

[Target]

Human Endogenous Metabolite

[In Vitro]

This dianion is very common in cells as the majority of glucose entering a cell will become phosphorylated in this way.

[References]

[1]. Olsen BB, et al. Linked Hexokinase and Glucose-6-Phosphatase Activities Reflect Grade of Ovarian Malignancy. Mol Imaging Biol. 2018 Jul 9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.97g/cm3

[ Boiling Point ]:
564.1ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₁₃O₉P

[ Molecular Weight ]:
260.13600

[ Flash Point ]:
295ºC

[ Exact Mass ]:
260.03000

[ PSA ]:
174.56000

[ Index of Refraction ]:
1.637

[ Storage condition ]:
−20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ7160000

CHEMICAL NAME :: D-Glucose, 6-(dihydrogen phosphate)

CAS REGISTRY NUMBER :: 56-73-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H13-O9-P

MOLECULAR WEIGHT :: 260.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 10 mmol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 81,105,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3153 No. of Facilities: 577 (estimated) No. of Industries: 3 No. of Occupations: 10 No. of Employees: 10643 (estimated) No. of Female Employees: 7844 (estimated)

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C

[ Risk Phrases ]:
34

[ Safety Phrases ]:
S26;S27;S45;S36/S37/S39

[ RIDADR ]:
UN 1760 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
LZ7160000

[ Packaging Group ]:
III

Synthetic Route

Click to get detail synthetic route

Articles

Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.

Org. Biomol. Chem. 10(48) , 9601-19, (2012)

The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their abi...

Reduced cellular Mg__ content enhances hexose 6-phosphate dehydrogenase activity and expression in HepG2 and HL-60 cells.

Arch. Biochem. Biophys. 548 , 11-9, (2014)

We have reported that Mg(2+) dynamically regulates glucose 6-phosphate entry into the endoplasmic reticulum and its hydrolysis by the glucose 6-phosphatase in liver cells. In the present study, we rep...

Teaching NeuroImages: diagnostic utility of FDG-PET in neurolymphomatosis.

Neurology 81(1) , e3, (2013)