CHIR 98014

Names

[ Name ]:
CHIR 98014

[Synonym ]:
2,6-Pyridinediamine, N-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-
N-(2-{[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino}ethyl)-3-nitro-2,6-pyridinediamine
CHIR-98014

Biological Activity

[Description]:

CHIR 98024 (Compound L) is a glycogen synthase kinase 3 (GSK3) inhibitor with an EC50 of 0.2566 μM[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3

Research Areas >> Neurological Disease

Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

GSK-3:0.2566 μM (EC50)

[References]

[1]. Stephen D. Harrison, et al. Methods and compositions for the treatment of ischemia. WO2003074072A1.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
839.0±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₇Cl₂N₉O₂

[ Molecular Weight ]:
486.314

[ Flash Point ]:
461.2±37.1 °C

[ Exact Mass ]:
485.088226

[ PSA ]:
163.25000

[ LogP ]:
3.76

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.753

Related Compounds

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