CHIR-124
Names
[ CAS No. ]:
405168-58-3
[ Name ]:
CHIR-124
[Synonym ]:
4-[(3S)-1-azabicyclo[2.2.2]oct-3-ylamino]-3-(1H-benzimidazol-2-yl)-6-chloroquinolin-2-ol
2(1H)-Quinolinone, 4-[(3S)-1-azabicyclo[2.2.2]oct-3-ylamino]-3-(1H-benzimidazol-2-yl)-6-chloro-
4-[(3S)-1-Azabicyclo[2.2.2]oct-3-ylamino]-3-(1H-benzimidazol-2-yl)-6-chloro-2(1H)-quinolinone
4-[(3s)-1-Azabicyclo[2.2.2]oct-3-Ylamino]-3-(1h-Benzimidazol-2-Yl)-6-Chloroquinolin-2(1h)-One
2-quinolinol, 4-[(3S)-1-azabicyclo[2.2.2]oct-3-ylamino]-3-(1H-benzimidazol-2-yl)-6-chloro-
pound not CHIR124 pound not CHIR 124
CHIR-124
UNII-5K64W8EU3E
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Chk1:0.3 nM (IC50)
Chk2:697.4 nM (IC50)
PDGFR:6.6 nM (IC50)
FLT3:5.8 nM (IC50)
Cdk4/cyclin D:2.05 μM (IC50)
CDC2/cyclin B:0.5057 μM (IC50)
Cdk2/cyclin A:0.1911 μM (IC50)
bFGFR:2.01 μM (IC50)
FGFR3:1.29 μM (IC50)
VEGFR2 FLK1:0.5779 μM (IC50)
VEGFR1 FLT1:0.4636 μM (IC50)
PKCα:0.58 μM (IC50)
PKAβ I:2.25 μM (IC50)
PKCβ II:0.58 μM (IC50)
PKCγ:0.11 μM (IC50)
ERK2:4.31 μM (IC50)
PKA:0.1031 μM (IC50)
GSK3:0.0233 μM (IC50)
[In Vitro]
[In Vivo]
[Kinase Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Molecular Formula ]:
C23H22ClN5O
[ Molecular Weight ]:
419.907
[ Exact Mass ]:
419.151276
[ PSA ]:
76.28000
[ LogP ]:
3.86
[ Index of Refraction ]:
1.750
[ Storage condition ]:
-20℃