CHIR-98023

Names

[ Name ]:
CHIR-98023

[Synonym ]:
unii-cmq1l0e91y
chir-837

Biological Activity

[Description]:

CHIR-98023 is a potent, selective and reversible inhibitor of GSK3, with IC50s of 10 nM and 6.7 nM for GSK3α and GSK3β, respectively. CHIR-98023 can improve insulin action and glucose metabolism[1][2].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

GSK3α:10 nM (IC50)

GSK3β:6.7 nM (IC50)

[References]

[1]. Cline GW, et, al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes. 2002 Oct;51(10):2903-10.

[2]. Hu M, et, al. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells. J Neurochem. 2008 Aug;106(3):1371-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₆Cl₂N₈O₂

[ Molecular Weight ]:
471.29900

[ Exact Mass ]:
470.07700

[ PSA ]:
143.69000

[ LogP ]:
4.03470

CHIR-98023

Names

Biological Activity

Chemical & Physical Properties

Related Compounds