Acetohydroxamic acid

Names

[ CAS No. ]:
546-88-3

[ Name ]:
Acetohydroxamic acid

[Synonym ]:
Acetamide, N-hydroxy-
Acetohydroxamic acid
methanecarbohydroxamic acid
EINECS 208-913-8
N-Hydroxyacetamide
N-acetylhydroxylamine
Acetomenadione
acethydroxamic acid
methylenehydroxamic acid
Acetylhydroxylamine
AHA
Lithostat
Acethydroxamsaure
MFCD00009994
Acetohydroxamic
Acetic acid,oxime
Acetic Acid Oxime

Biological Activity

[Description]:

Acetohydroxamic acid is a potent and irreversible inhibitor of bacterial and plant urease and also used as adjunctive therapy in chronic urinary infection.Target: UreaseAcetohydroxamic acid selectively inhibits arachidonate 5-lipoxygenase and thus has potential use in the treatment of asthma.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[References]

[1]. Sharma M, et al. Biotransformation of Acetamide to Acetohydroxamic Acid at Bench Scale Using Acyl Transferase Activity of Amidase of Geobacillus pallidus BTP-5x MTCC 9225. Indian J Microbiol. 2012 Mar;52(1):76-82.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
231.4ºC at 760 mmHg

[ Melting Point ]:
88-90 °C(lit.)

[ Molecular Formula ]:
C₂H₅NO₂

[ Molecular Weight ]:
75.067

[ Exact Mass ]:
75.032028

[ PSA ]:
49.33000

[ LogP ]:
-1.59

[ Index of Refraction ]:
1.421

[ Stability ]:
Moisture and Temperature Sensitive

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AK8157000

CHEMICAL NAME :: Acetohydroxamic acid

CAS REGISTRY NUMBER :: 546-88-3

LAST UPDATED :: 199410

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C2-H5-N-O2

MOLECULAR WEIGHT :: 75.08

WISWESSER LINE NOTATION :: QMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 750 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 20 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 152,225,1985

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360

[ Precautionary Statements ]:
P201-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R61

[ Safety Phrases ]:
S53-S45

[ RIDADR ]:
3263

[ WGK Germany ]:
3

[ RTECS ]:
AK8157000

[ Packaging Group ]:
II

[ HS Code ]:
2942000000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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