dethiobiotin

Names

[ CAS No. ]:
533-48-2

[ Name ]:
dethiobiotin

[Synonym ]:
DL-DESTHIOBIOTIN
6-[(4R,5S)-5-Methyl-2-oxo-4-imidazolidinyl]hexanoic acid
6-(5-methyl-2-oxo-imidazolidin-4-yl)hexanoic acid
4-Imidazolidinehexanoic acid, 5-methyl-2-oxo-, (4R,5S)-
(4R-cis)-5-methyl-2-oxoimidazolidine-4-hexanoic acid
Desthiobiotin
1H-Imidazole-5-hexanoic acid, 4,5-dihydro-2-hydroxy-4-methyl-, (4S,5R)-
dethiobiotin
d-Desthiobiotin
5-METHYL-2-OXO-4-IMIDAZOLINE-CAPROIC ACID
[4R,5S,(+)]-5-Methyl-2-oxo-4-imidazolidinehexanoic acid
5-Methyl-2-oxo-4-imidazolidinehexanoic acid
D(-)-desthiobiotin
(4R,5S)-dethiobiotin
6-[(4R,5S)-5-Methyl-2-oxoimidazolidin-4-yl]hexanoic acid

Biological Activity

[Description]:

D-Desthiobiotin is a biotin derivative used in affinity chromatography and protein chromatography, also can be used for protein and cell labeling, detection and isolation[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Röhlen DL, et al. Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes. Front Chem. 2018 Jul 17;6:284.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
476.4±18.0 °C at 760 mmHg

[ Melting Point ]:
156-158 °C

[ Molecular Formula ]:
C₁₀H₁₈N₂O₃

[ Molecular Weight ]:
214.262

[ Flash Point ]:
241.9±21.2 °C

[ Exact Mass ]:
214.131744

[ PSA ]:
78.43000

[ LogP ]:
0.31

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.473

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Easily reversible desthiobiotin binding to streptavidin, avidin, and other biotin-binding proteins: uses for protein labeling, detection, and isolation.

Anal. Biochem. 308 , 343-357, (2002)

The high-affinity binding of biotin to avidin, streptavidin, and related proteins has been exploited for decades. However, a disadvantage of the biotin/biotin-binding protein interaction is that it is...

Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation.

Proc. Natl. Acad. Sci. U. S. A. 108(49) , 19581-19586, (2011)

The process of lipid droplet (LD) formation is an evolutionarily conserved process among all eukaryotes and plays an important role in both cellular physiology and disease. Recently, fat storage-induc...

Mutagenesis of a flexible loop in streptavidin leads to higher affinity for the Strep-tag II peptide and improved performance in recombinant protein purification.

Protein Eng. 10(8) , 975-982, (1997)

The Strep-tag, an artificial peptide ligand of streptavidin, has gained use as an affinity handle for the purification and detection of recombinant fusion proteins. In an attempt to achieve tighter co...

Related Compounds

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