D-Biotin
Names
[ CAS No. ]:
58-85-5
[ Name ]:
D-Biotin
[Synonym ]:
D(+)-Biotin
1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS,4S,6aR)-
cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid
(+)-Biotin
EINECS 200-399-3
Bios-IIb
biotina
(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid
Rovimix H2
biotine
Rovimix H 2
Vitamin H
BIOS H
1H-Thieno[3,4-d]imidazole-6-pentanoic acid, 3a,4,6,6a-tetrahydro-2-hydroxy-, (3aR,6S,6aS)-
5-[(3aR,6S,6aS)-2-Hydroxy-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl]pentanoic acid
5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid
biotin
Meribin
Ritatin
BIOTINUM
Lutavit H2
MFCD00005541
Factor S
biosii
Biodermatin
D-(+)-Biotin
D-Biotin
Vitamin B7
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
492.3±55.0 °C at 760 mmHg
[ Melting Point ]:
231-233 °C(lit.)
[ Molecular Formula ]:
C10H16N2O3S
[ Molecular Weight ]:
244.311
[ Flash Point ]:
251.5±31.5 °C
[ Exact Mass ]:
244.088165
[ PSA ]:
103.73000
[ LogP ]:
0.03
[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C
[ Index of Refraction ]:
1.717
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XJ9088200
- CHEMICAL NAME :
- 1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3a-alpha,4-beta, 6a-alpha))-
- CAS REGISTRY NUMBER :
- 58-85-5
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C10-H16-N2-O3-S
- MOLECULAR WEIGHT :
- 244.34
- WISWESSER LINE NOTATION :
- T55 BMVM GSTJ H4VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 14-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19- 1973- Volume(issue)/page/year: 22,181,1976
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 42,613,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 1-2 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- REFERENCE :
- JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19- 1973- Volume(issue)/page/year: 21,89,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 17 mg/kg
- SEX/DURATION :
- female 1-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
- REFERENCE :
- EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 52,149,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80381 No. of Facilities: 129 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 8306 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80381 No. of Facilities: 1674 (estimated) No. of Industries: 9 No. of Occupations: 41 No. of Employees: 46583 (estimated) No. of Female Employees: 22672 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
20/21/22-36/37/38
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
XJ9088200
[ HS Code ]:
29362930
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Nutr. 144(12) , 1977-84, (2014)
Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequa...
Characterization and tissue distribution of conjugated metabolites of pyrene in the rat.J. Vet. Med. Sci. 77 , 1261-7, (2015)
Pyrene (PY) is a polycyclic aromatic hydrocarbon (PAH) that is often used as a biomarker for human and wildlife exposure to PAHs. As the metabolites of PAHs, similar to their parent compounds, pose pu...
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Chem. Res. Toxicol. 23 , 171-83, (2010)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...