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Corydaline

Names

[ CAS No. ]:
518-69-4

[ Name ]:
Corydaline

[Synonym ]:
13aβ-Berbine, 2,3,9,10-tetramethoxy-13α-methyl-
(13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
d-Corydalin
(13S,13aR)-2,3,9,10-Tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline
(13S-trans )-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo[a,g]quinolizine
Corydaline (+)
6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-, (13S,13aR)-
Berbine,2,3,9,10-tetramethoxy-13-methyl
2,3,9,10-Tetramethoxy-13a-methyl-13ab-berbine
(13S,13aR)-2,3,9,10-Tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline
Corydalin
Corydaline

Biological Activity

[Description]:

Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> AChE
Natural Products >> Alkaloid
Research Areas >> Neurological Disease

[References]

[1]. Xiao HT, et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011 Sep;25(15):1418-22.


[Related Small Molecules]

Galantamine | Choline glycerophosphate | benzethonium chloride | Malathion | (-)-Huperzine A | pyridostigmine bromide | Scopoletin | Tacrine hydrochloride hydrate | Huperzine A | Epiberberine chloride | Protriptyline hydrochloride | Imperatorin | Itopride hydrochloride | Enzacamene | Drofenine hydrochloride

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
482.3±45.0 °C at 760 mmHg

[ Melting Point ]:
135°

[ Molecular Formula ]:
C22H27NO4

[ Molecular Weight ]:
369.454

[ Flash Point ]:
135.7±25.9 °C

[ Exact Mass ]:
369.194000

[ PSA ]:
40.16000

[ LogP ]:
4.19

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.600

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN0600000
CHEMICAL NAME :
Corydaline
CAS REGISTRY NUMBER :
518-69-4
BEILSTEIN REFERENCE NO. :
0096972
LAST UPDATED :
199709
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H27-N-O4
MOLECULAR WEIGHT :
369.50
WISWESSER LINE NOTATION :
T D6 B666 KN&TT&J C1 GO1 HO1 PO1 QO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
136 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,163,1946

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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