Osthenol

Names

[ CAS No. ]:
484-14-0

[ Name ]:
Osthenol

[Synonym ]:
7-Hydroxy-8-Prenyl coumarin
Osthenol

Biological Activity

[Description]:

Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[Target]

hMAO-A:0.26 μM (Ki)

hMAO-A:0.74 μM (IC50)

[References]

[1]. Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843.

[2]. Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003.

Chemical & Physical Properties

[ Density]:
1.203g/cm3

[ Boiling Point ]:
422.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₄O₃

[ Molecular Weight ]:
230.25900

[ Flash Point ]:
184.1ºC

[ Exact Mass ]:
230.09400

[ PSA ]:
50.44000

[ LogP ]:
3.00730

[ Vapour Pressure ]:
9.53E-08mmHg at 25°C

[ Index of Refraction ]:
1.595

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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