484-14-0

484-14-0 structure

Name: Osthenol
Chemical Name: 7-hydroxy-8-(3-methylbut-2-enyl)chromen-2-one
CAS Number: 484-14-0
Molecular Formula: C₁₄H₁₄O₃
Molecular Weight: 230.25900
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2018-05-16 08:00:00
Modify Date: 2024-01-06 18:07:00
Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B[1].

Name	7-hydroxy-8-(3-methylbut-2-enyl)chromen-2-one
Synonyms	7-Hydroxy-8-Prenyl coumarin Osthenol

Description	Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	hMAO-A:0.26 μM (Ki) hMAO-A:0.74 μM (IC50)
References	[1]. Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843. [2]. Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003.

484-14-0	35052-35-8
74730-08-8	87702-90-7