Methyl 2-chloroacetoacetate

[ Density]:
1.236 g/mL at 25 °C(lit.)

[ Boiling Point ]:
137 °C(lit.)

[ Melting Point ]:
−33-−32.7 °C(lit.)

[ Molecular Formula ]:
C₅H₇ClO₃

[ Molecular Weight ]:
150.56000

[ Flash Point ]:
161 °F

[ Exact Mass ]:
150.00800

[ PSA ]:
43.37000

[ LogP ]:
0.35580

[ Index of Refraction ]:
n20/D 1.446(lit.)

[ Storage condition ]:
2~8°C

[ Water Solubility ]:
50 g/L (20 ºC)

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S37/39

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29183000

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Chemoselective arylamidine cyclizations: mild formation of 2-arylimidazole-4-carboxylic acids.

Org. Lett. 7(17) , 3801-3, (2005)

A versatile, one-pot synthesis of 2-arylimidazole-4-carboxylic acids from arylamidines and methyl-2-chloroacetoacetate is described. The transformation is chemoselective, and reaction conditions are m...

'One-flask'synthesis to 3, 5-disubstituted 1, 2, 4-triazoles from aldehydes with hydrazonoyl hydrochlorides via 1, 3-dipolar cycloaddition. Tseng W-C, et al.

Tetrahedron 67(29) , 5339-45, (2011)

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