1,4-Dithiane
Names
[ CAS No. ]:
505-29-3
[ Name ]:
1,4-Dithiane
[Synonym ]:
1,4-Dithiane
Tetrahydro-1,4-dithiin,
p-Dithiane
dihydro-1,4-dithiin
EINECS 208-007-2
1,4-Dithiacyclohexane
Diethylene disulfide
1,4-dithian
MFCD00006658
1,4-Dithiin,tetrahydro
p-Dithiin,tetrahydro
p-Dithane
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
200.5±15.0 °C at 760 mmHg
[ Melting Point ]:
110-112ºC
[ Molecular Formula ]:
C4H8S2
[ Molecular Weight ]:
120.236
[ Flash Point ]:
82.1±17.4 °C
[ Exact Mass ]:
120.006737
[ PSA ]:
50.60000
[ LogP ]:
1.12
[ Vapour Pressure ]:
0.5±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.574
[ Storage condition ]:
2-8°C
[ Stability ]:
Stable. Incompatible with strong oxidizing agents. Probably combustible.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- JO5069000
- CHEMICAL NAME :
- p-Dithiane
- CAS REGISTRY NUMBER :
- 505-29-3
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C4-H8-S2
- MOLECULAR WEIGHT :
- 120.24
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2768 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18900 mg/kg/90D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 4 umol/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 321,213,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4362 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
UN 3335
[ WGK Germany ]:
2
[ RTECS ]:
JO5069000
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Mutat. Res. 321(4) , 213-8, (1994)
1,3-Dithiane and 1,4-dithiane are the sulfur-containing Maillard reaction products (MRPs) which have been found in boiled beef extracts. In this study the genotoxicity of these products was examined u...
Analysis, characterization, and purification: requirements for toxicological evaluation of 1,4-dithiane.J. Chromatogr. A. 467(1) , 159-66, (1989)
1,4-Dithiane is an organo-sulfur chemical associated with production and storage of munitions. Toxicological evaluation of this chemical was scheduled in rats because of the paucity of such informatio...