coniferyl aldehyde

Names

[ CAS No. ]:
458-36-6

[ Name ]:
coniferyl aldehyde

[Synonym ]:
Ferulaldehyde
(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal
(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal
Ferulyl aldehyde
2-Propenal, 3-(4-hydroxy-3-methoxyphenyl), (E)-
4-hydroxy-3-methoxy-benzaldehyde
MFCD00075811
4-hydroxy-3-methoxy-cinnamon-aldehyde
2-Propenal, 3-(4-hydroxy-3-methoxyphenyl)-, (2E)-
coniferaldehyde
4-hydroxy-3-methoxycinnamic aldehyde
EINECS 207-278-4
4-HYDROXY-3-METHOXYCINNAMALDEHYDE
(2E)-3-(4-Hydroxy-3-methoxyphenyl)acrylaldehyde
coniferyl aldehyde
Coniferylaldehyde

Biological Activity

[Description]:

Coniferaldehyde (Ferulaldehyde), isolated from the ethanol extract of Vitex rotundifolia fruits, is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde exerts anti-inflammatory properties in response to LPS. Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Kim KM, et al. Coniferaldehyde inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Environ Toxicol Pharmacol. 2016 Dec;48:85-93.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
338.8±27.0 °C at 760 mmHg

[ Melting Point ]:
80-82ºC(lit.)

[ Molecular Formula ]:
C₁₀H₁₀O₃

[ Molecular Weight ]:
178.185

[ Flash Point ]:
136.8±17.2 °C

[ Exact Mass ]:
178.062988

[ PSA ]:
46.53000

[ LogP ]:
1.35

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.593

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2912499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2912499000

[ Summary ]:
2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry.

J. Mass Spectrom. 49(8) , 665-73, (2014)

Imaging mass spectrometry (IMS) studies increasingly focus on endogenous small molecular weight metabolites and consequently bring special analytical challenges. Since analytical tissue blanks do not ...

Reagent precoated targets for rapid in-tissue derivatization of the anti-tuberculosis drug isoniazid followed by MALDI imaging mass spectrometry.

J. Am. Soc. Mass Spectrom. 22(8) , 1409-19, (2011)

Isoniazid (INH) is an important component of front-line anti-tuberculosis therapy with good serum pharmacokinetics but unknown ability to penetrate tuberculous lesions. However, endogenous background ...

Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits.

J. Agric. Food Chem. 53(8) , 2922-7, (2005)

In the continuous search for antifungal compounds from plants, the hydroxycoumarin scopoletin (1) was isolated from seed kernels of Melia azedarach L. from which three other compounds, vanillin (2), 4...

Related Compounds

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