Yakuchinone A

Names

[ Name ]:
Yakuchinone A

[Synonym ]:
yakuchinone-A
1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-3-heptanone
yadanzioside-N

Biological Activity

[Description]:

Yakuchinone A is a natural product isolated from the fruit of Alpinia oxyphylla, which can induce apoptosis and has anticancer and anti-inflammatory activities[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[In Vitro]

Yakuchinone A 作用于 A375P、B16F1、B16F10、A549、MCF-7 和 HT-29 细胞系的 IC50 值分别是 14.75、31.73、21.71、26.07 、11.50 和 11.96[1]。 Yakuchinone A (0-64 μM, 16 h) 可以剂量依赖性方式减少 IL-17 的产生，在 EL4（小鼠淋巴瘤细胞系）细胞中的 IC50 值为 11.5 μM[2] 。

[In Vivo]

Yakuchinone A (50 mg/kg, i.p., daily, 14 days) 在自身免疫性脑脊髓炎 (EAE) 小鼠模型中可以减轻小鼠的 EAE 症状[1]。 Animal Model: Female C57BL/6 mice[1] Dosage: 50 mg/kg Administration: i.p., daily, 14 days Result: Showed a significant EAE score reduction from Day 9 to Day 15 after EAE onset.

[References]

[1]. Chen Huo, et al. Microbial Transformation of Yakuchinone A and Cytotoxicity Evaluation of Its Metabolites. Int J Mol Sci. 2022 Apr 3;23(7):3992.

[2]. Kuo-Kuei Huang, et al. Alpinia oxyphylla Fruit Extract Ameliorates Experimental Autoimmune Encephalomyelitis through the Regulation of Th1/Th17 Cells. Evid Based Complement Alternat Med. 2019 Mar 14;2019:6797030.

Chemical & Physical Properties

[ Density]:
1.095g/cm3

[ Boiling Point ]:
495.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₄O₃

[ Molecular Weight ]:
312.40

[ Flash Point ]:
174.3ºC

[ Exact Mass ]:
312.17300

[ PSA ]:
46.53000

[ LogP ]:
4.31550

[ Index of Refraction ]:
1.559

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Related Compounds

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