EGFR-IN-52

Names

[ CAS No. ]:
454436-75-0

[ Name ]:
EGFR-IN-52

Biological Activity

[Description]:

EGFR-IN-52 (Compound 4) is a potent EGFR inhibitor with IC50 values of 0.358, 86.02 and 432.67 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-52 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR:0.358 μM (IC50)

EGFRL858R:86.02 μM (IC50)

EGFRT790M:432.67 μM (IC50)


[References]

[1]. Abbas SY, et al. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. Eur J Med Chem. 2020 Jul 15;198:112363.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H18N4O3S

[ Molecular Weight ]:
382.44

Related Compounds