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EGFR-IN-27

Names

[ CAS No. ]:
2752328-62-2

[ Name ]:
EGFR-IN-27

Biological Activity

[Description]:

EGFR-IN-27 is a potent EGFR inhibitor with IC50s of <50 nM for EGFR Del, L858R, Del/T790M, L858R/T790M, Del/T790M/C797S, and L858R/T790M/C797S, respectively (WO2021249324A1, compound 511)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFRdel19:<50 nM (IC50)

EGFRL858R:<50 nM (IC50)

EGFRL858R/T790M:<50 nM (IC50)

EGFRdel19 T790M C797S:<50 nM (IC50)

EGFR (C797S/T790M/L858R):<50 nM (IC50)

EGFRdel19 T790M:<50 nM (IC50)


[References]

[1]. Alkenyl pyrimidine compound, preparation method therefor, and application thereof. WO2021249324A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C35H46N9O2P

[ Molecular Weight ]:
655.77

Related Compounds