454436-75-0

454436-75-0 structure

Name: EGFR-IN-52
Chemical Name: EGFR-IN-52
CAS Number: 454436-75-0
Molecular Formula: C₁₉H₁₈N₄O₃S
Molecular Weight: 382.44
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-01 12:24:16
Modify Date: 2025-08-27 21:09:50
EGFR-IN-52 (Compound 4) is a potent EGFR inhibitor with IC50 values of 0.358, 86.02 and 432.67 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-52 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].

Name	EGFR-IN-52

Description	EGFR-IN-52 (Compound 4) is a potent EGFR inhibitor with IC50 values of 0.358, 86.02 and 432.67 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-52 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:0.358 μM (IC50) EGFRL858R:86.02 μM (IC50) EGFRT790M:432.67 μM (IC50)
References	[1]. Abbas SY, et al. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. Eur J Med Chem. 2020 Jul 15;198:112363.

Molecular Formula	C₁₉H₁₈N₄O₃S
Molecular Weight	382.44