6-Hydroxykaempferol

Names

[ Name ]:
6-Hydroxykaempferol

[Synonym ]:
3,5,6,7,4'-Pentahydroxy-flaven-4-on
3,4',5,6,7-pentahydroxyflavone
6-Hydroxy-kaempferol
6-Hydroxykaempferol

Biological Activity

[Description]:

6-Hydroxykaempferol, a flavonoid, is a competitive tyrosinase inhibitor with an IC50 value of 124 μM. 6-Hydroxykaempferol has a Ki value of 148 μM relative to L-DOPA as a substrate and effectively inhibits the activity of the enzyme by binding to the active site of the enzyme[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Hong Gao, et al. Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase. Molecules. 2007 Jan 29;12(1):86-97.

Chemical & Physical Properties

[ Density]:
1.799g/cm3

[ Boiling Point ]:
669.3ºC at 760 mmHg

[ Melting Point ]:
>320 ºC (ethanol )

[ Molecular Formula ]:
C₁₅H₁₀O₇

[ Molecular Weight ]:
302.23600

[ Flash Point ]:
258.4ºC

[ Exact Mass ]:
302.04300

[ PSA ]:
131.36000

[ LogP ]:
1.98800

[ Index of Refraction ]:
1.823

[ Water Solubility ]:
Very slightly soluble (0.24 g/L) (25 ºC)

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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