5-HT1A modulator 2 hydrochloride

Names

[ Name ]:
5-HT1A modulator 2 hydrochloride

[Synonym ]:
8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
2-Naphthalenamine, 1,2,3,4-tetrahydro-8-methoxy-, hydrochloride (1:1)
1,2,3,4-Tetrahydro-8-methoxy-2-naphthalenamine hydrochloride
8-Methoxy-1,2,3,4-tetrahydro-2-naphthalenamine hydrochloride (1:1)
8-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1)
8-methoxy-2-amino tetralin hydrochloride
2-Amino-8-methoxytetralin hydrochloride
2-Amino-8-methoxy-1,2,3,4-tetrahydronaphthalenehydrochloride
dl-1,2,3,4-tetrahydro-8-methoxy-2-naphthalenamine hydrochloride
8-Methoxy-1,2,3,4-tetrahydronaphthalen-2-aMine
8-Methoxy-(2R)-2-amino-1,2,3,4-tetrahydronaphthalene hydrochloride
8-Methoxy-2-amino-1,2,3,4-tetrahydronaphthalene hydrochloride
8-methoxy-1,2,3,4-tetrahydro naphthalen-2-amine

Biological Activity

[Description]:

5-HT1A modulator 2 hydrochloride, a derivative of 8-OH-DPAT (HY-112061), is a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

Ki: 53 nM (5-HT1A)[1]

[In Vitro]

5-HT1A modulator 2 hydrochloride (compound 3) binds to 5-HT1A with a Ki of 53 nM[1].

[References]

[1]. Naiman, N.,et al. 2-(Alkylamino)tetralin derivatives: interaction with 5-HT1A serotonin binding sites. Journal of Medicinal Chemistry, 1989;32(1), 253–256.

Chemical & Physical Properties

[ Boiling Point ]:
341.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₆ClNO

[ Molecular Weight ]:
213.704

[ Flash Point ]:
160.2ºC

[ Exact Mass ]:
213.092041

[ PSA ]:
35.25000

[ LogP ]:
3.01350

Safety Information

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%