Triptonide

Names

[ Name ]:
Triptonide

[Synonym ]:
l-triptonide
Triptolide,14-deoxy-14-oxo
Triptonide
(3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-Isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione
Trisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione, 3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-
14-Deoxy-14-oxotriptolide
(3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-8b-methyl-6a-(propan-2-yl)-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione

Biological Activity

[Description]:

Triptonide(NSC 165677; PG 492), extracted from Tripterygium wilfordii Hook, inhibited the proliferation of mouse splenocytes induced by suboptimal concentration of concanavalin A or lipopolysaccharide at concentrations of 0.02, 0.1, and 0.5 mg/ml.

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> β-catenin

Signaling Pathways >> Stem Cell/Wnt >> Wnt

Research Areas >> Others

Natural Products >> Terpenoids and Glycosides

[References]

[1]. Wu YW, Jiang YY, Xiao TX, Zhang HL.Determination of triptonide by cloud point extraction combined with MEKC.J Sep Sci. 2008 Mar;31(5):865-71.

[2]. Yao J, Zhang L, Zhao X, Hu L, Jiang Z.Simultaneous determination of triptolide, wilforlide A and triptonide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry.Biol Pharm Bull. 2006 Jul;29(7):1483-6.

[3]. Wang Z, Wen J, Xing J, Guo D.Determination of triptolide and triptonide in human plasma by high-performance liquid chromatography.Biomed Chromatogr. 2005 Jan;19(1):60-2.

[4]. Wang L, Ye W, Hui L, Liu X, Guo Y.[Male contraception of triptonide and its function mechanism].Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Jun;22(3):223-6.

[5]. Corson, Timothy W.; Cavga, Hueseyin; Aberle, Nicholas; Crews, Craig M. Triptolide Directly Inhibits dCTP Pyrophosphatase. ChemBioChem (2011), 12(11), 1767-1773.

[Related Small Molecules]

XAV-939 | ICG-001 | Salinomycin | IWR-1 | Wnt-C59 | Berberine chloride hydrate | Pyrvinium pamoate | ETC-159 | BML 284 | IWP-2 | Heparan Sulfate | KYA 1797K | FH535 | SKL2001 | CCT251545

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
581.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₂O₆

[ Molecular Weight ]:
358.385

[ Flash Point ]:
257.8±30.2 °C

[ Exact Mass ]:
358.141632

[ PSA ]:
80.96000

[ LogP ]:
1.49

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.638

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H330-H361f

[ Precautionary Statements ]:
P201-P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233

[ Hazard Codes ]:
T+

[ RIDADR ]:
2811.0

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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