IWP-2
Names
[ CAS No. ]:
686770-61-6
[ Name ]:
IWP-2
[Synonym ]:
N-(6-Methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-
IWP-2
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: 27 nM (Wnt)[1]
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Melting Point ]:
257 °C(dec.)
[ Molecular Formula ]:
C22H18N4O2S3
[ Molecular Weight ]:
466.599
[ Exact Mass ]:
466.059174
[ PSA ]:
156.11000
[ LogP ]:
5.25
[ Index of Refraction ]:
1.787
[ Storage condition ]:
Store at +4°C
[ Water Solubility ]:
DMSO: >5mg/mL
Safety Information
[ RIDADR ]:
NONH for all modes of transport
Articles
PLoS ONE 9(6) , e98698, (2014)
Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model organism for breast cancer research. In order to obtain an insight into underlying signaling mechani...
Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.Proc. Natl. Acad. Sci. U. S. A. 112(1) , 166-71, (2015)
The activation of cochlear progenitor cells is a promising approach for hair cell (HC) regeneration and hearing recovery. The mechanisms underlying the initiation of proliferation of postnatal cochlea...
A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells.Stem Cells 32(12) , 3196-208, (2014)
Wnt/β-catenin signaling is essential for neurogenesis but less is known about β-catenin-independent Wnt signals. We show here that Wnt/activator protein-1 (AP-1) signaling drives differentiation of hu...