(R)-Verapamil hydrochloride

Names

[ Name ]:
(R)-Verapamil hydrochloride

[Synonym ]:
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride

Biological Activity

[Description]:

(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer drugs[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[References]

[1]. Plumb JA, et al. The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific. Biochem Pharmacol. 1990 Feb 15;39(4):787-92.

[2]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.

Chemical & Physical Properties

[ Melting Point ]:
129-131℃

[ Molecular Formula ]:
C₂₇H₃₉ClN₂O₄

[ Molecular Weight ]:
477.03600

[ Exact Mass ]:
476.24400

[ PSA ]:
65.15000

[ LogP ]:
0.43398

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
23/24/25

[ Safety Phrases ]:
22-36/37/39-45

[ RIDADR ]:
UN 2811 6.1/PG 3