(S)-Verapamil hydrochloride

Names

[ Name ]:
(S)-Verapamil hydrochloride

[Synonym ]:
s(-)-verapamil
MFCD00069355
EINECS 253-132-8

Biological Activity

[Description]:

(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor

[Target]

LTC4

Ca2+

[In Vitro]

(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells[1]. (S)-Verapamil hydrochloride is good active form and has the low bioavailability[1].

[References]

[1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.

[2]. Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₉ClN₂O₄

[ Molecular Weight ]:
491.06300

[ Exact Mass ]:
490.26000

[ PSA ]:
63.95000

[ LogP ]:
5.89508

MSDS

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Safety Information

[ RIDADR ]:
UN 2811 6.1/PG 3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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