36622-28-3

36622-28-3 structure

Name: (S)-Verapamil hydrochloride
Chemical Name: S(−)-Verapamil hydrochloride hydrate
CAS Number: 36622-28-3
Molecular Formula: C₂₇H₃₉ClN₂O₄
Molecular Weight: 491.06300
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-21 18:58:00
Modify Date: 2024-01-05 11:30:15
(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1].

Name	S(−)-Verapamil hydrochloride hydrate
Synonyms	s(-)-verapamil MFCD00069355 EINECS 253-132-8

Description	(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor
Target	LTC4 Ca2+
In Vitro	(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells[1]. (S)-Verapamil hydrochloride is good active form and has the low bioavailability[1].
References	[1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22. [2]. Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.

RIDADR	UN 2811 6.1/PG 3

102201-30-9

36622-28-3

36622-23-8

36622-28-3

20850-49-1

36622-28-3

Precursor 3
102201-30-9 36622-23-8 20850-49-1
DownStream 0