A scaleable route to the pure enantiomers of verapamil

RM Bannister, MH Brookes, GR Evans…

Index: Organic Process Research and Development, , vol. 4, # 6 p. 467 - 472

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Citation Number: 15

Abstract

... After removing excess amine 11 with an aqueous acid wash, the organic solution was ... Despite the convenience of the reduction procedure, it is still only suitable for large ... BMS mediated reduction, we are confident that further development work will deliver a satisfactory process. ...