3-Chloro-4-fluoroaniline

Names

[ CAS No. ]:
367-21-5

[ Name ]:
3-Chloro-4-fluoroaniline

[Synonym ]:
3-Chloro-4-fluoroaniline
para-fluoro-meta-chloroaniline
Benzenamine, 3-chloro-4-fluoro-
3-chlor-4-fluoranilin
3-Chloro-4-fluorobenzenamine
3-Cl-4-F-aniline
4-fluoro-3-chloro-aniline
Benzenamine,3-chloro-4-fluoro
3-Chloro-4-fluorophenylamine
Aniline,3-chloro-4-fluoro
EINECS 206-682-8
3-chloro-4-fluoro aniline
3-chloro-4-fluoroanilline
MFCD00007767
CHLOROFLUOROANILINE

Biological Activity

[Description]:

4-Fluoro-3-chloroaniline is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

吉非替尼杂质 V 是一种有机氟化结构单元，用于合成药物和生物活性化合物。它具有抗炎活性。

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
227.5±0.0 °C at 760 mmHg

[ Melting Point ]:
42-44 °C(lit.)

[ Molecular Formula ]:
C₆H₅ClFN

[ Molecular Weight ]:
145.56

[ Flash Point ]:
99.4±21.8 °C

[ Exact Mass ]:
145.009460

[ PSA ]:
26.02000

[ LogP ]:
2.14

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.570

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates. May be air-sensitive.

[ Water Solubility ]:
10 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H373

[ Precautionary Statements ]:
P261-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R23/24/25;R33

[ Safety Phrases ]:
S36/37/39-S45-S26

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
2

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29214210

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Reductive deamination as a new step in the anaerobic microbial degradation of halogenated anilines.

FEMS Microbiol. Lett. 209(2) , 307-12, (2002)

In this paper we report the isolation and characterization of an anaerobic enrichment culture as well as of a Rhodococcus sp. strain 2 capable of degrading 3,4-dihaloanilines under nitrate reducing co...

An improved analytical method, based on HPLC with electrochemical detection, for monitoring exposure to 3-chloro-4-fluoroaniline.

J. Anal. Toxicol. 12(6) , 330-3, (1988)

An HPLC method for monitoring exposure of workers to 3-chloro-4-fluoroaniline (CFA) is described. It is based on the detection of a major urinary metabolite, 2-amino-4-chloro-5-fluorophenyl sulphate, ...

Biological monitoring of exposure to 3-chloro-4-fluoroaniline by determination of a urinary metabolite and a hemoglobin adduct.

Environ. Health Perspect. 102 Suppl 6 , 23-5, (1994)

In two studies, involving 75 and 72 workers, potential exposure to 3-chloro-4-fluoroaniline (CFA) was biologically monitored by determination of its main urinary metabolite 2-amino-4-chloro-5-fluoroph...