4-Bromo-2-chloro-1-fluorobenzene

Names

[ Name ]:
4-Bromo-2-chloro-1-fluorobenzene

[Synonym ]:
1-bromo-4-fluoro-3-chloro-benzene
4-Bromo-2-chlorofluorobenzene
1-bromo-3-chloro-4-fluorobenzene
3-Chloro-4-fluorobromobenzene
3-Chloro-4-fluorobenzene bromide
GR BF EE
EINECS 405-580-2
Benzene, 4-bromo-2-chloro-1-fluoro-
1-fluoro-2-chloro-4-bromobenzene
4-Bromo-2-chloro-1-fluorobenzene
MFCD00051794

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
196.4±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₃BrClF

[ Molecular Weight ]:
209.443

[ Flash Point ]:
72.6±21.8 °C

[ Exact Mass ]:
207.909058

[ LogP ]:
3.63

[ Vapour Pressure ]:
0.6±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.551

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H410

[ Precautionary Statements ]:
P273-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R38;R50/53

[ Safety Phrases ]:
S26-S36/37-S60-S61

[ RIDADR ]:
UN 3082 9/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
9

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor.

Chemistry 20(1) , 263-71, (2014)

Conducting low-temperature organometallic reactions under continuous flow conditions offers the potential to more accurately control exotherms and thus provide more reproducible and scalable processes...

Efficient synthesis of a GABA A alpha2,3-selective allosteric modulator via a sequential Pd-catalyzed cross-coupling approach.

J. Org. Chem. 70(15) , 6034-6039, (2005)

A practical synthesis of 2-[3-(4-fluoro-3-pyridin-3-yl-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-propan-2-ol (1), an oral GABA(A) alpha(2/3)-selective agonist, is described. The five-step process, which a...