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5-Hydroxypyrazine-2-carboxylic acid

Names

[ CAS No. ]:
34604-60-9

[ Name ]:
5-Hydroxypyrazine-2-carboxylic acid

[Synonym ]:
5-hydroxyopyrazine-2-carboxylic acid
5-hydroxy-pyrazine-2-carboxylic acid
2-Carboxy-5-hydroxypyrazine
5-hydroxypyrazinoic acid
5-Hydroxypyrazine-2-carboxylic acid
5-Hydroxy-2-pyrazinecarboxylic acid
5-hydroxy-2-pyrazinedicarboxylic acid
5-Oxo-4,5-dihydro-2-pyrazinecarboxylic acid
6-Hydroxy-3-pyridazinecarboxylic acid
5-Hydroxypyrazinecarboxylic Acid
5-HYDROXYPYRAZINE-3-CARBOXYLIC ACID
2-Pyrazinecarboxylic acid, 5-hydroxy-
5-Hydroxypyrazinoic acid-13C3
5-Hydropyrazine-2-carboxylic acid
5-oxo-4,5-dihydro-pyrazine-2-carboxylic acid
MFCD00190599

Biological Activity

[Description]:

5-hydroxypyrazine-2-carboxylic acid , a metabolite of anti-tuberculosis drug pyrazinamide (PZA).

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial
Research Areas >> Others

[References]

[1]. Huq, Fazlul; Hossain, Zahed. Molecular modelling analysis of the metabolism of pyrazinamide. Journal of Pharmacology and Toxicology (2006), 1(6), 505-515.

[2]. Mehmedagic, Aida; Verite, Philippe; Menager, Sabine et al. Investigation of the effects of concomitant caffeine administration on the metabolic disposition of pyrazinamide in rats. Biopharmaceutics & Drug Disposition (2002), 23(5), 191-195.


[Related Small Molecules]

Puromycin 2HCl | Geneticin | Tunicamycin | Hygromycin B | Salinomycin | Avibactam sodium | Neomycin sulfate | Vaborbactam | Methicillin SodiuM | Rifampicin | Metronidazole | Carbenicillin disodium | Ceftazidime | Eravacycline dihydrochloride | cefotaxime sodium

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
608.5ºC at 760 mmHg

[ Melting Point ]:
>295°C (dec.)

[ Molecular Formula ]:
C5H4N2O3

[ Molecular Weight ]:
140.097

[ Flash Point ]:
321.8ºC

[ Exact Mass ]:
140.022186

[ PSA ]:
83.31000

[ LogP ]:
-1.71

[ Index of Refraction ]:
1.662

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds