L-Thioproline

Names

[ Name ]:
L-Thioproline

[Synonym ]:
H-THZ-OH
L-Thiazolidine-4-car
(R)-4-Thiazolidinecarboxylic acid
EINECS 252-106-3
L-THC
THIAPROLINE
(4R)-4-Thiazolidinecarboxylic acid
(4R)-thiazolidine-4-carboxylic acid
1,3-Thiazolidine-2-carboxylic acid
Thiazolidinecarboxylic acid (VAN)
THIAZOLIDINECARBOXYLIC ACID
2-Thiazolidinecarboxylic acid
DL-Thiazolidinecarboxylic acid
L(-)-Thiazolidine-4-carboxylicacid
L(-)-Thiazolidine-4-Carboxylic Acid
L-Thiazolidine-4-carboxylic acid
H-L-THZ-OH
MFCD00005212
(4R)-1,3-Thiazolidine-4-carboxylic acid
L-4-Thiazolidinecarboxylic acid
L-Thioproline
thiazolidinecarboxylicacid
(R)-(-)-4-Thiazolidinecarboxylic acid
L- thiazolidine-4-carboxylic acid
THIOPROLINE
H-THIOPRO-OH
L-THIAPROLINE
(R)-Thiazolidine-4-carboxylic acid
(R)-(-)-Thiazolidine-4-carboxylic Acid
L-thiazoline-4-carboxylic acid
4-Thiazolidinecarboxylic acid, (4R)-

Biological Activity

[Description]:

(R)-Thiazolidine-4-carboxylic acid is a proline derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
350.3±37.0 °C at 760 mmHg

[ Melting Point ]:
190-200 °C (dec.)(lit.)

[ Molecular Formula ]:
C₄H₇NO₂S

[ Molecular Weight ]:
133.169

[ Flash Point ]:
165.7±26.5 °C

[ Exact Mass ]:
133.019745

[ PSA ]:
74.63000

[ LogP ]:
-0.39

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.566

[ Water Solubility ]:
28.5 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ5425500

CHEMICAL NAME :: 4-Thiazolidinecarboxylic acid, L-

CAS REGISTRY NUMBER :: 34592-47-7

LAST UPDATED :: 199610

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H7-N-O2-S

MOLECULAR WEIGHT :: 133.18

WISWESSER LINE NOTATION :: T5M CSTJ EVQ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2547728

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00644

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26-S36/37/39-S36

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
XJ5425500

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
29341000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).

Bioorg. Med. Chem. 19 , 6409-18, (2011)

The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitati...

Design, synthesis and biological evaluation of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors.

Biochimie 94(2) , 533-40, (2012)

Herein we describe the design, synthesis and biological activities of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors. The target compounds 2a-2j were d...

Successful computer guided planned synthesis of (4R)-thiazolidine carboxylic acid and its 2-substituted analogues as urease inhibitors.

Mol. Divers. 10(2) , 223-31, (2006)

By using internal combinatorial library we were able to identify (4R)-thiazolidines carboxylic acid and its 2-substituted analogs as active inhibitors of urease. Molecular modeling and virtual screeni...

Related Compounds

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