VU 0285683

Names

[ Name ]:
VU 0285683

Biological Activity

[Description]:

VU0285683 is a selective mGluR5 positive allosteric modulator (PAM). VU0285683 has anxiolytic-like activity in rodent models for anxiety[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[References]

[1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₇FN₄O

[ Molecular Weight ]:
266.23000

[ Exact Mass ]:
266.06000

[ PSA ]:
75.60000

[ LogP ]:
2.80938

Related Compounds

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