327056-22-4

327056-22-4 structure

Name: VU 0285683
Chemical Name: 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
CAS Number: 327056-22-4
Molecular Formula: C₁₄H₇FN₄O
Molecular Weight: 266.23000
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2019-01-10 12:37:30
Modify Date: 2025-08-22 10:25:50
VU0285683 is a selective mGluR5 positive allosteric modulator (PAM). VU0285683 has anxiolytic-like activity in rodent models for anxiety[1].

Name	3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile

Description	VU0285683 is a selective mGluR5 positive allosteric modulator (PAM). VU0285683 has anxiolytic-like activity in rodent models for anxiety[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
References	[1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23.