N-Acetyl-D-lactosamine

Names

[ Name ]:
N-Acetyl-D-lactosamine

[Synonym ]:
N-Acetyl-D-lactosamine
N-Acetyllactosamine
N-ACETYLLACTOSAMINE

Biological Activity

[Description]:

N-Acetyllactosamine (LacNAc), a nitrogen-containing disaccharide, is an important component of various oligosaccharides such as glycoproteins and sialyl Lewis X. N-Acetyllactosamine can be used as the starting material for the synthesis of various oligosaccharides. N-Acetyllactosamine has prebiotic effects[1][2].

[Related Catalog]:

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Endo T, Koizumi S, Tabata K, Kakita S, Ozaki A. Large-scale production of N-acetyllactosamine through bacterial coupling. Carbohydr Res. 1999 Mar 31;316(1-4):179-83.

[2]. M.Karimi Alavijeh, et al. Simulation and economic assessment of large-scale enzymatic N-acetyllactosamine manufacture. Biochemical Engineering Journal. Volume 154, 15 February 2020, 107459

Chemical & Physical Properties

[ Density]:
1.64 g/cm3

[ Boiling Point ]:
805.5ºC at 760 mmHg

[ Melting Point ]:
191-192ºC

[ Molecular Formula ]:
C₁₄H₂₅NO₁₁

[ Molecular Weight ]:
383.34800

[ Flash Point ]:
441ºC

[ Exact Mass ]:
383.14300

[ PSA ]:
198.40000

[ Index of Refraction ]:
1.623

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 10 mg/mL, clear, colorless

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

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J. Pharmacol. Exp. Ther. 353 , 505-16, (2015)

c-Jun N-terminal kinases (JNKs) participate in many physiologic and pathologic processes, including inflammatory diseases. We recently synthesized the sodium salt of IQ-1S (11H-indeno[1,2-b]quinoxalin...

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.

J. Exp. Med. 212 , 883-92, (2015)

B cell activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic survival of mature B cells. Earlier in vitro experiments with inhibitors that block MEK 1 and...

Plasmacytoid Dendritic Cell Infection and Sensing Capacity during Pathogenic and Nonpathogenic Simian Immunodeficiency Virus Infection.

J. Virol. 89 , 6918-27, (2015)

Human immunodeficiency virus (HIV) in humans and simian immunodeficiency virus (SIV) in macaques (MAC) lead to chronic inflammation and AIDS. Natural hosts, such as African green monkeys (AGM) and soo...