6-Aminonicotinic acid

Names

[ Name ]:
6-Aminonicotinic acid

[Synonym ]:
5-carboxy-2-aminopyridine
6-Aminonicotinicacid
6-Imino-1,6-dihydro-3-pyridinecarboxylic acid
3-Pyridinecarboxylic acid, 6-amino-
6-aminopyridine-3-carboxylic acid
Nicotinic acid,6-amino
2-amino-5-carboxypyridine
EINECS 221-630-4
Cinchomeronic acid
3-Pyridinecarboxylic acid, 1,6-dihydro-6-imino-
3-Pyridinecarboxylic acid,6-amino
2-Amino-5-pyridinecarboxylic acid
6-Aminonicotinic acid
2-aminopyridine-5-carboxylic acid
MFCD00006326
T6NJ BZ EVQ
6-Amino nicotinic acid

Biological Activity

[Description]:

6-Aminonicotinic acid is a GABAA receptor agonist with Ki value of 4.4 nM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
222.6±50.0 °C at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C₆H₆N₂O₂

[ Molecular Weight ]:
138.124

[ Flash Point ]:
88.4±30.1 °C

[ Exact Mass ]:
138.042923

[ PSA ]:
76.21000

[ LogP ]:
-0.74

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.630

[ Water Solubility ]:
ca 1.0 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi,T

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Two genetically distinct pathways for transcriptional regulation of anaerobic gene expression in Salmonella typhimurium.

J. Bacteriol. 168(1) , 389-97, (1986)

Expression of the tripeptide permease gene tppB is anaerobically induced. This induction is independent of the fnr (oxrA) gene product, which is known to be required for the anaerobic induction of sev...

NAD metabolism in Salmonella typhimurium: isolation of pyridine analogue supersensitive (pas) and pas suppressor mutants.

J. Gen. Microbiol. 130(11) , 2873-81, (1984)

Mutants of Salmonella typhimurium supersensitive to the nicotinic acid analogue 6-amino-nicotinic acid (6ANA) were isolated as unable to grow on what are normally subinhibitory concentrations of the a...

Electrocatalytic synthesis of 6-aminonicotinic acid at silver cathodes under mild conditions. Gennaro A, et al.

Electrochem. Commun. 6(7) , 627-31, (2004)