SMER28

Names

[ Name ]:
SMER28

[Synonym ]:
6-Bromo-N-2-propenyl-4-quinazolinamine 6-bromo-N-2-propenyl-4-quinazolinamine
SMER28
3srb

Biological Activity

[Description]:

SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Cancer

[References]

[1]. Renna M et al. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem. 2010 Apr 9;285(15):11061-7.

[2]. Shen D et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem Biophys. 2011 Jul;60(3):173-85.

[3]. Tian Y et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25(6):1934-42.

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
169 °C

[ Molecular Formula ]:
C₁₁H₁₀BrN₃

[ Molecular Weight ]:
264.12100

[ Exact Mass ]:
263.00600

[ PSA ]:
41.04000

[ LogP ]:
2.41210

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

Articles

Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies.

Cell Biochem. Biophys. 60 , 173-85, (2011)

Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous f...

Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes.

J. Biol. Chem. 290 , 13028-38, (2015)

Chondrocyte-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-classical protein secretion, intercellular communication, and pathologic calcification. Fac...

Related Compounds

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