SMER28

Modify Date: 2025-08-21 22:54:12

SMER28 structure	Common Name	SMER28
	CAS Number	307538-42-7	Molecular Weight	264.12100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₀BrN₃	Melting Point	169 °C
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of SMER28

SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.

Name	6-bromo-N-prop-2-enylquinazolin-4-amine
Synonym	More Synonyms

Description	SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer
References	[1]. Renna M et al. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem. 2010 Apr 9;285(15):11061-7. [2]. Shen D et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem Biophys. 2011 Jul;60(3):173-85. [3]. Tian Y et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25(6):1934-42.

Description

SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Cancer

References

[1]. Renna M et al. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem. 2010 Apr 9;285(15):11061-7.

[2]. Shen D et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem Biophys. 2011 Jul;60(3):173-85.

[3]. Tian Y et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25(6):1934-42.

Melting Point	169 °C
Molecular Formula	C₁₁H₁₀BrN₃
Molecular Weight	264.12100
Exact Mass	263.00600
PSA	41.04000
LogP	2.41210
InChIKey	BCPOLXUSCUFDGE-UHFFFAOYSA-N
SMILES	C=CCNc1ncnc2ccc(Br)cc12

SMER28 MSDS(Chinese)

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
RIDADR	NONH for all modes of transport

Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies.

Cell Biochem. Biophys. 60 , 173-85, (2011)

Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous f...

Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes.

J. Biol. Chem. 290 , 13028-38, (2015)

Chondrocyte-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-classical protein secretion, intercellular communication, and pathologic calcification. Fac...

6-Bromo-N-2-propenyl-4-quinazolinamine 6-bromo-N-2-propenyl-4-quinazolinamine

SMER28

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China
Product Name: SMER28
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Purity: 98.0%
Delivery: 3 Day
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Price: $66/10mM*1mLinDMSO

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SMER28

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