Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SMER28
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: SMER28
Price: ￥5056.0/100mg ￥2626.0/50mg ￥676.0/10mg ￥1356.0/25mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: SMER28
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: SMER28
Price: $350.0/100mg $600.0/250mg $1350.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

307538-42-7

307538-42-7 structure

307538-42-7 structure

Name: SMER28
Chemical Name: 6-bromo-N-prop-2-enylquinazolin-4-amine
CAS Number: 307538-42-7
Molecular Formula: C₁₁H₁₀BrN₃
Molecular Weight: 264.12100
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2016-06-08 06:33:05
Modify Date: 2025-08-21 22:54:12
SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.

Name	6-bromo-N-prop-2-enylquinazolin-4-amine
Synonyms	6-Bromo-N-2-propenyl-4-quinazolinamine 6-bromo-N-2-propenyl-4-quinazolinamine SMER28 3srb

Description	SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer
References	[1]. Renna M et al. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem. 2010 Apr 9;285(15):11061-7. [2]. Shen D et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem Biophys. 2011 Jul;60(3):173-85. [3]. Tian Y et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25(6):1934-42.

Melting Point	169 °C
Molecular Formula	C₁₁H₁₀BrN₃
Molecular Weight	264.12100
Exact Mass	263.00600
PSA	41.04000
LogP	2.41210

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
RIDADR	NONH for all modes of transport

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