3-Methoxy-L-tyrosine

Names

[ CAS No. ]:
300-48-1

[ Name ]:
3-Methoxy-L-tyrosine

[Synonym ]:
L-Tyrosine,3-Methoxy
3-OMD
3-(4-hydroxy-3-methoxyphenyl)-L-alanine
L-3-(3-methoxy-4-hydroxyphenyl)alanine
L-3-(4-hydroxy-3-methoxyphenyl)-alanine
3-METHOXY-L-TYROSINE
4-HYDROXY-3-METHOXY-L-PHENYLALANINE DIHYDRATE
L-3-methoxytyrosine
3-O-methyl-3,4-dihydroxyphenylalanine
3-METHOXY-TYROSINE
L-3-O-METHYL-DOPA DIHYDRATE
3-Methoxy-DOPA

Biological Activity

[Description]:

3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Masato Asanuma, et al. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC Neurosci. 2016 Jul 25;17(1):52.

Chemical & Physical Properties

[ Density]:
1.321g/cm3

[ Boiling Point ]:
407.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₃NO₄

[ Molecular Weight ]:
211.21500

[ Flash Point ]:
200.1ºC

[ Exact Mass ]:
211.08400

[ PSA ]:
92.78000

[ LogP ]:
1.05550

[ Index of Refraction ]:
1.591

Safety Information

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%