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Ursocholic acid

Names

[ CAS No. ]:
2955-27-3

[ Name ]:
Ursocholic acid

[Synonym ]:
3-Epicholic acid
3|A-Cholic Acid
3|A,7|A,12|A-Trihydroxy-5|A-cholanoic Acid

Biological Activity

[Description]:

Ursocholic acid, a bile acid found predominantly in bile of mammals, is an inhibitor of 7α-hydroxysteroid dehydrogenase and hepatocyte nuclear factor 1α.

[Related Catalog]:

Natural Products >> Others
Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite


[References]

[1]. MacDonald IA, et al. Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms. Appl Environ Microbiol. 1982 Nov;44(5):1187-95.

[2]. Lee HI, et al. Ursodeoxycholic acid, an inhibitor of hepatocyte nuclear factor 1α, did not increase the systemic exposure of pitavastatin. Int J Clin Pharmacol Ther. 2014 Nov;52(11):981-5.


[Related Small Molecules]

3-Methyladenine | Hydrocortisone | Acetylcysteine(N-acetylcysteine) | Retinoic acid | Melatonine | Dinoprostone | Nicotinamide | Adenosine triphosphate | 4-Acetamidophenol | Prostaglandin E1 | Dehydroepiandrosterone | Corticosterone | Progesterone | Docosahexaenoic Acid | NAD+

Chemical & Physical Properties

[ Density]:
1.184g/cm3

[ Boiling Point ]:
583.9ºC at 760mmHg

[ Molecular Formula ]:
C24H40O5

[ Molecular Weight ]:
408.57100

[ Flash Point ]:
321ºC

[ Exact Mass ]:
408.28800

[ PSA ]:
97.99000

[ LogP ]:
3.44870

[ Storage condition ]:
2-8℃

Related Compounds

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