T0901317

Names

[ Name ]:
T0901317

[Synonym ]:
N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE
Benzenesulfonamide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
MFCD03412028
N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
T0901317

Biological Activity

[Description]:

T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FXR

Signaling Pathways >> Metabolic Enzyme/Protease >> LXR

Research Areas >> Cancer

[References]

[1]. Ding H et al. LXR agonist T0901317 upregulates thrombomodulin expression in glomerular endothelial cells by inhibition of nuclear factor?κB. Mol Med Rep. 2016 Jun;13(6):4888-96

[2]. Baranowski M et al. Insulin-sensitizing effect of LXR agonist T0901317 in high-fat fed rats is associated with restored muscle GLUT4 expression and insulin-stimulated AS160 phosphorylation. Cell Physiol Biochem. 2014;33(4):1047-5

[Related Small Molecules]

Obeticholic acid | GW4064 | GW3965 HCl | Tropifexor | WAY 252623 | INT-767 | Fexaramine | SR 9243 | (20S)-Protopanaxatriol | 27-Hydroxycholesterol | GSK 2033 | AZ876 | Chenodeoxycholic acid | SR 9238 | XL335

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
470.5±55.0 °C at 760 mmHg

[ Melting Point ]:
116-122° C

[ Molecular Formula ]:
C₁₇H₁₂F₉NO₃S

[ Molecular Weight ]:
481.333

[ Flash Point ]:
238.4±31.5 °C

[ Exact Mass ]:
481.039429

[ PSA ]:
65.99000

[ LogP ]:
4.82

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.491

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport.

J. Nutr. Biochem. 26(2) , 165-72, (2015)

High-density lipoproteins (HDLs) are atheroprotective because of their role in reverse cholesterol transport. The intestine is involved in this process because it synthesizes HDL, removes cholesterol ...

RNA binding protein HuR regulates the expression of ABCA1.

J. Lipid Res. 55(6) , 1066-1076, (2014)

ABCA1 is a major regulator of cellular cholesterol efflux and plasma HDL biogenesis. Even though the transcriptional activation of ABCA1 is well established, the posttranscriptional regulation of ABCA...

Effect of compounds affecting ABCA1 expression and CETP activity on the HDL pathway involved in intestinal absorption of lutein and zeaxanthin.

Lipids 49(12) , 1233-43, (2014)

The antioxidant xanthophylls lutein and zeaxanthin are absorbed from the diet in a process involving lipoprotein formation. Selective mechanisms exist for their intestinal uptake and tissue-selective ...

Related Compounds

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