INT-767

Names

[ CAS No. ]:
1000403-03-1

[ Name ]:
INT-767

Biological Activity

[Description]:

INT-767 is a dual farnesoid X receptor/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FXR

Signaling Pathways >> GPCR/G Protein >> GPCR19

Research Areas >> Cancer

[References]

[1]. Baghdasaryan A, et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mousecholangiopathy model by promoting biliary HCO3- output. Hepatology. 2011 Oct;54(4):1303-1312.

[2]. Rizzo G, et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor andTGR5 agonist. Mol Pharmacol. 2010 Oct;78(4):617-630.

[Related Small Molecules]

Obeticholic acid | INT-777 | GW4064 | T0901317 | Tropifexor | Fexaramine | Chenodeoxycholic acid | XL335 | Deoxycholic acid | BAR501 | TGR5 | Androsterone | PX20606 trans racemate | SB756050 | BAR502

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₄₃NaO₆S

[ Molecular Weight ]:
494.66

[ Storage condition ]:
2-8℃

Related Compounds

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