PX20606 trans racemate

Names

[ Name ]:
PX20606 trans racemate

[Synonym ]:
6TU6SUZ3BY
UNII:6TU6SUZ3BY
UNII:378SU5NO8S
Benzoic acid, 4-[(1S,2S)-2-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]cyclopropyl]-
4-[(1S,2S)-2-(2-Chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)cyclopropyl]benzoic acid
378SU5NO8S
PX20606 trans racemate

Biological Activity

[Description]:

PX20606 trans racemate is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FXR

Research Areas >> Metabolic Disease

[Target]

EC50: 32 nM (FXR in FRET assay), 34 nM (FXR in M1H assay)[1]

[References]

[1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.

[Related Small Molecules]

Obeticholic acid | GW4064 | T0901317 | Tropifexor | INT-767 | Fexaramine | Chenodeoxycholic acid | XL335 | Androsterone | (-)-PX20606 trans isomer | BAR502 | Cilofexor | LY2562175

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₂Cl₃NO₄

[ Molecular Weight ]:
554.85

[ Storage condition ]:
2-8℃

Related Compounds

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