BChE/HDAC6-IN-2

Names

[ CAS No. ]:
2925457-33-4

[ Name ]:
BChE/HDAC6-IN-2

Biological Activity

[Description]:

BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Research Areas >> Neurological Disease
Signaling Pathways >> Epigenetics >> HDAC
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

IC50: 1.8 nM (BChE), 71.0 nM (HDAC6)


[References]

[1]. Wang L, Sun T, Wang Z, Liu H, Qiu W, Tang X, Guo H, Yang P, Chen Y, Sun H. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2023 Sep 6;14(17):3226-3248.  

Chemical & Physical Properties

[ Molecular Formula ]:
C27H30N4O4

[ Molecular Weight ]:
474.55

Related Compounds

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