2925457-33-4

2925457-33-4 structure

Name: BChE/HDAC6-IN-2
Chemical Name: BChE/HDAC6-IN-2
CAS Number: 2925457-33-4
Molecular Formula: C₂₇H₃₀N₄O₄
Molecular Weight: 474.55
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2024-07-22 23:16:59
Modify Date: 2024-07-22 23:16:59
BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.

Name	BChE/HDAC6-IN-2

Description	BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 1.8 nM (BChE), 71.0 nM (HDAC6)
References	[1]. Wang L, Sun T, Wang Z, Liu H, Qiu W, Tang X, Guo H, Yang P, Chen Y, Sun H. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2023 Sep 6;14(17):3226-3248.

Molecular Formula	C₂₇H₃₀N₄O₄
Molecular Weight	474.55