BChE/HDAC6-IN-1

Names

[ CAS No. ]:
2925457-27-6

[ Name ]:
BChE/HDAC6-IN-1

Biological Activity

[Description]:

BChE/HDAC6-IN-1 is a potent and selective dual BChE/HDAC6 inhibitor with IC50 values of 4 and 8.9 nM, respectively. BChE/HDAC6-IN-1 ameliorates the cognitive impairment in an Aβ1–42-induced mouse model and has the potental for AD research[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Research Areas >> Neurological Disease
Signaling Pathways >> Epigenetics >> HDAC
Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Lei Wang, ET AL. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2023 Sep 6;14(17):3226-3248.  

Chemical & Physical Properties

[ Molecular Formula ]:
C34H43N5O5

[ Molecular Weight ]:
601.74

Related Compounds

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